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Elaboration of a porous structure of Eudragit E100 by coupling extrusion and supercritical CO2 : from experimental design to phenomenological understanding of process

Abstract : Extrusion is a process already used industrially for converting a raw material into a product of uniform shape. The aim of this study is the development of a supercritical carbon dioxide CO2-assisted extrusion process which leads to the manufacturing of polymeric foams. This coupling is integrated in the present trends of process engineering. Indeed, we obtain a process without residues, without chemical blowing agent and with smooth operating conditions for new applications. In this study, we have identified the significant operating parameters and we have approached the key phenomena in order to obtain a porous matrix. With a view to a pharmaceutical applications, a biocompatible polymer was used, Eudragit E100. Within this context, experimental equipment has been designed based on a single-screw extruder in order to be able to inject supercritical CO2 within the material to be extruded. Supercritical CO2 modifies the rheological properties of the material and consequently the flow in the barrel of the extruder. After a tracer validation, the residence time distribution and particulate flow have been determined. A flow model based on ideal reactors was developed and the effect of temperature, screw speed and flow rate of CO2 was studied. A central composite statistical design and an image analysis Matlab software designed in the laboratory allow to determine the correlation between operating conditions and product characteristics, (i.e. expansion, cell size and cell density) and process mechanisms, (i.e. mixing, nucleation, growth and coalescence phenomena).
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https://hal-mines-albi.archives-ouvertes.fr/tel-02936569
Contributor : Imt Mines Albi Ecole Nationale Supérieure Des Mines d'Albi-Carmaux <>
Submitted on : Friday, September 11, 2020 - 2:07:04 PM
Last modification on : Sunday, September 13, 2020 - 3:05:51 AM

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  • HAL Id : tel-02936569, version 1

Citation

Clémence Nikitine. Elaboration of a porous structure of Eudragit E100 by coupling extrusion and supercritical CO2 : from experimental design to phenomenological understanding of process. Chemical and Process Engineering. École nationale supérieure des mines de Paris, 2007. English. ⟨NNT : 2007ENMP1489⟩. ⟨tel-02936569⟩

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