Mesure et modélisation de la solubilité des composés solides dans des fluides supercritiques: application à la génération de poudres

Abstract : Supercritical technology offers an alternative to conventional processes for generating powder. The thermodynamical behaviour of the solubility of the solid compound in supercritical phases is key data for process design. Within this context, a novel apparatus for the accurate measurement of the solubility of solid compounds in supercritical phases has been designed and developed. It is based on the analytical open circuit method. Its validation has been achieved by means of naphthalene solubility measurements in supercritical carbon dioxide (CO2). This device has been applied to the study of a pharmaceutical compound. Its solubility has been measured in pure supercritical CO2 and in CO2-cosolvent mixtures (ethanol and dimethylsulfoxide) for different temperatures, pressures and cosolvent mole fractions. These data have been correlated by means of density-based semi-empirical models. Density is obtained by using the Peng-Robinson (1976( equation of state. Chrastil's (1982) model has been extended to cosolvent mixtures. The relation of Mendez-Santiago and Teja (2000) has enabled the representation of all the data with a single relation which is a function of density, temperature and supercritical mixture composition. An approach to supercritical process design for powder generation (RESS, RESS with cosolvent and SAS) can be proposed on the basis of all these results.
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Martial Sauceau. Mesure et modélisation de la solubilité des composés solides dans des fluides supercritiques: application à la génération de poudres. Génie des procédés. Mines Paristech - Ecole des Mines de Paris, 2001. Français. ⟨tel-01858696⟩

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