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Synthesis of Biologically Relevant 1,2,3-and 1,3,4-Triazoles: From Classical Pathway to Green Chemistry: Review

Abstract : Green Chemistry has become in the last two decades an increasing part of research interest. Nonconventional «green» sources for chemical reactions include micro-wave, mechanical mixing, visible light and ultrasound. 1,2,3-triazoles have important applications in pharmaceutical chemistry while their 1,2,4 counterparts are developed to a lesser extent. In the review presented here we will focus on synthesis of 1,2,3 and 1,2,4-triazole systems by means of classical and « green chemistry » conditions involving ultrasound chemistry and mechanochemistry. The focus will be on compounds/scaffolds that possess biological/pharmacophoric properties. Finally, we will also present the formal cycloreversion of 1,2,3-triazole compounds under mechanical forces and its potential use in biological systems.
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Submitted on : Friday, October 1, 2021 - 10:15:37 AM
Last modification on : Tuesday, October 19, 2021 - 2:20:21 PM

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Lori Gonnet, Michel Baron, Michel Baltas. Synthesis of Biologically Relevant 1,2,3-and 1,3,4-Triazoles: From Classical Pathway to Green Chemistry: Review. Molecules, MDPI, 2021, 26 (18), pp.5667. ⟨10.3390/molecules26185667⟩. ⟨hal-03360993⟩

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