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Generation of high drug loading amorphous solid dispersions by Spray Drying

Abstract : Amorphous solid dispersions (ASDs) refers to drug - carrier systems, where the drug is dispersed in the carrier at a molecular level. In this work, ASDs were formulated by spray drying. The aim was to achieve high drug loads of an amorphous hydrophobic drug (Efavirenz - EFV) in the carrier Soluplus (R). Solid state characterizations (mDSC, XRPD, DVS, Raman, SEM, stability and solubility studies) were done. EFV amorphisation in ASDs (20 to 85% EFV loads) resulted in improved drug solubility compared to unprocessed EFV crystals and tendency of properties evolution over time for ASDs with EFV loads higher than 70 wt%.
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Bhianca Lins de Azevedo Costa, Martial Sauceau, Romain Sescousse, Maria-Inês Ré. Generation of high drug loading amorphous solid dispersions by Spray Drying. IDS 2018 - 21st International Drying Symposium, Sep 2018, Valence, Spain. pp.1123-1130, ⟨10.4995/ids2018.2018.7871⟩. ⟨hal-02267499⟩



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