Abstract : Amorphous solid dispersions (ASDs) refers to drug - carrier systems, where the drug is dispersed in the carrier at a molecular level. In this work, ASDs were formulated by spray drying. The aim was to achieve high drug loads of an amorphous hydrophobic drug (Efavirenz - EFV) in the carrier Soluplus (R). Solid state characterizations (mDSC, XRPD, DVS, Raman, SEM, stability and solubility studies) were done. EFV amorphisation in ASDs (20 to 85% EFV loads) resulted in improved drug solubility compared to unprocessed EFV crystals and tendency of properties evolution over time for ASDs with EFV loads higher than 70 wt%.
https://hal-mines-albi.archives-ouvertes.fr/hal-02267499
Contributor : Imt Mines Albi Ecole Nationale Supérieure Des Mines d'Albi-Carmaux
<>
Submitted on : Monday, August 19, 2019 - 1:14:21 PM
Last modification on : Thursday, November 7, 2019 - 4:28:02 PM
Long-term archiving on: Thursday, January 9, 2020 - 11:07:35 PM
