Dry granulation process modeling

Abderrahim Michrafy 1 A. Zavaliangos 2 John Cunningham 3
1 RAPSODEE - Centre de recherche d'Albi en génie des procédés des solides divisés, de l'énergie et de l'environnement
2 SIMaP - Science et Ingénierie des Matériaux et Procédés
3 Trinity College Dublin
Abstract : Dry granulation is a powder agglomeration process used in the pharmaceutical industry to improve the flowability of powders by increasing the particle size (granules). This operation is achieved using a roller press, which can have different configurations and equipment designs. Progress in experimental investigations has allowed confirming the impact of the process on granules properties and tableting, however full understanding of the process remains difficult. The development of a predictive model for roller compaction is promising to provide insight and to allow significantly advance the understanding and design of the process. In this work, a review of existing modeling and experimental validations are reported and discussed. The main focus was on the modeling of the process using the finite element method (FEM). It was demonstrated that FEM modeling of the roller compaction process offers a versatile approach to bring guidance and practical solutions that can be used to optimize design and process development. However, currently there is a lack of experimental information under relevant process conditions to improve the quality of predictions. Only few and partial experimental validations of two-dimensional and three-dimensional FEM for modeling pharmaceutical applications have been attempted.
Keywords : Dry granulation roll compaction modeling FEM DEM validation
Document type :
Book sections
Complete list of metadatas
https://hal-mines-albi.archives-ouvertes.fr/hal-01693629
Contributor : Imt Mines Albi Ecole Nationale Supérieure Des Mines d'Albi-Carmaux <>
Submitted on : Friday, January 26, 2018 - 1:43:52 PM
Last modification on : Thursday, November 7, 2019 - 10:02:02 AM

Identifiers

Collections

MINES-ALBI | RAPSODEE | CNRS | UGA | INC-CNRS

Citation

Abderrahim Michrafy, A. Zavaliangos, John Cunningham. Dry granulation process modeling. Predictive Modeling of Pharmaceutical Unit Operations (chap. 4), Elsevier, p.71-97, 2017, Woodhead publishing series in biomedicine ; 87, 978-0-08-100154-7. ⟨10.1016/B978-0-08-100154-7.00004-1⟩. ⟨hal-01693629⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

307

Contact

Informations

CCSD