Control of solvated crystallization of α-lactose (alpha-lactose) monohydrate

Amira Rachah 1 Dominikus Noll 1 F. Espitalier 2 Fabien Baillon 2
1 IMT - Institut de Mathématiques de Toulouse UMR5219
2 RAPSODEE - Centre de recherche d'Albi en génie des procédés des solides divisés, de l'énergie et de l'environnement
Abstract : We present a mathematical model of solvated crystallization of α-lactose monohydrate and discuss strategies to control the crystallization process in semi-batch mode with the goal to privilege the production of small particles in the range between 130 µm and 330 µm. We compare specific and unspecific cost functions leading to optimal strategies with significantly different effects on product quality. Control inputs are temperature, feed rate, and the choice of an appropriate crystal seed.
Keywords : population dynamics optimal control thermodynamic balance molar balance Solvated crystallization
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Amira Rachah, Dominikus Noll, F. Espitalier, Fabien Baillon. Control of solvated crystallization of α-lactose (alpha-lactose) monohydrate. International Journal of Mathematical Modelling and Numerical Optimisation, Inderscience, 2015, 6 (2), ⟨10.1504/IJMMNO.2015.069968⟩. ⟨hal-01686106⟩

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